Formosa Pharmaceuticals Technology
Technology Advantages｜APNT® nanoparticle formulation platform
APNT® is an innovative and breakthrough technology compared with other particle size reduction platforms:
How does APNT® work ?
APNT® does not employ metal or plastic “beads” and therefore avoids contamination derived from fragmentation from bead collision and grinding. APNT® products have high purity, as it utilizes salts or sugars for milling, which can remain as part of the final formulation.
APNT® nanoparticle formulation technology
Beads Milling
APNT® Technology vs. Other Particle Size Reduction Platforms
| Key features | APNT® Technology | Other Particle Size Reduction Platforms (Beads-Milling, NanoEdge™, Cryomilling) | |
|---|---|---|---|
| Aseptic Filtration is possible | * Narrow particle size distribution and the particle size of APNT nanolized API can be less than 200nm to pass aseptic filter (0.2 micron). | ||
| Tunable particle size & narrow particle size distribution |
* Difficult in tuning particle size
* NanoEdge™ has broad particle distribution . |
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| Preservation of crystal structure | * Cryomilling: amorphization of material from crystal cracking at low temperature | ||
| Adequate operational temperature |
* Beads-Milling generates high temperature which may affect API.
* Cryomilling requires extremely low temperatures. |
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| Free of solvents and harsh additives |
* Use of organic solvents that may remain in final product and present possible toxicology or allergen risk
* Beads-Milling use of harsh additives that remain in final product |
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| Low contamination risk | * Beads-Milling has higher contamination risk from beads. | ||
| All excipients are GRAS level | * APNT®: All excipients are GRAS (Generally Regarded As Safe) | ||
APNT® Can help your asset by
